| The 4th Virtual Training Workshop on Bioinformatics |
| Kyushu Institute of Technology, Fukuoka, Japan (on-line) |
| September 13, 2010 |
| 38 |
| Oral presentation (on-line) |
| Inference of DNA methylation and its evolution from the ratio of observed to expected number of CpG |
|
Kohji Okamura1 1Ctr. Inf. Biol., Ochanomizu Univ., Japan |
|
Among the 16 DNA dinucleotides, the CpG is unique in terms of its frequency in genomic sequences. This fact results from the DNA methylation system observed in a wide range of organisms. Curiously, especially to computational biologists, methylated and unmethylated regions can be reliably predicted from the ratio of observed to expected number of CpG dinucleotides. Moreover, by analyzing global patterns of DNA methylation, we can even follow the evolutionary changes in the epigenetic modification. |